ORF Virus Treatment

Preventing sepsis begins with preventing infection, says the chief medical officer of Sepsis Alliance. In a typical year, more than 350,000 adult Americans die of sepsis—a number that could be lowered with better recognition of signs and symptoms of sepsis by everyone on a care team, says the chief medical officer of Sepsis Alliance, the nation's first and leading sepsis organization. "It should be everyone's responsibility," says Cindy Hou, DO, MA, MBA, CIC, CPHQ, FACOI, FACP, FIDSA, Sepsis Alliance's chief medical officer. Dr. Hou also is the infection control officer and medical director of research at New Jersey's Jefferson Health. "And the reason I say 'everybody' is just imagine that physical therapy comes to a person's home or to long-term care and they are doing careful assessments every single day. They may notice [signs of sepsis]. That's why, in my opinion, everybody should be engaged," she says. A 2018 DePaul University st...

Abstract The human gastric epithelium forms highly organized gland structures with different subtypes of cells. The carcinogenic bacterium Helicobacter pylori can attach to gastric cells and subsequently translocate its virulence factor CagA, but the possible host cell tropism of H. pylori is currently unknown. Here, we report that H. pylori preferentially attaches to differentiated cells in the pit region of gastric units. Single-cell RNA-seq shows that organoid-derived monolayers recapitulate the pit region, while organoids capture the gland region of the gastric units. Using these models, we show that H. pylori preferentially attaches to highly differentiated pit cells, marked by high levels of GKN1, GKN2 and PSCA. Directed differentiation of host cells enable enrichment of the target cell population and confirm H. pylori preferential attachment and CagA translocation into these cells. Attachment is independent of MUC5AC or PSCA expression, and instead relies on bacterial TlpB-...

Years after it was first proven to work, a new tool for preventing sexually transmitted infections (STIs) is on the brink of entering mainstream medicine. That tool is doxyPEP, an antibiotic that works like a morning-after pill — but instead of preventing pregnancy within hours of unprotected sex, it prevents STIs like chlamydia and syphilis. Ever since a 30-person trial first suggested hope for the strategy in 2015, people worldwide have begun trying doxyPEP for themselves, often without the approval or supervision of a medical provider. About 10 percent of men who have sex with men in Europe and Australia are using the medication, often purchasing it from online pharmacies or sources that don't require a prescription, and Facebook groups for HIV PrEP users teem with testimonials and advice. But on October 21, the San Francisco health department became the first authority in the US to release guidance recommending doxyPEP for men with recent STIs — especially syphilis — and ...

The Herald George Maponga and Mandaza Chikarango Zimbabwe is in the process of producing 15 million doses of vaccine against Newcastle to protect poultry. The Department of Veterinary Services is producing the vaccine, to save the poultry in communal areas. The Presidential Rural Poultry Scheme was launched in Masvingo last week and about 3 million rural households will each receive 10 chicks over the next two to three years. At the moment, there are reports that some farmers in Goromonzi, Mashonaland East Province, have lost considerable numbers of chickens due to the Newcastle disease, making the production of the vaccine timely. The Department of Veterinary Services says there are plans to vaccinate chickens countrywide as part of the Government's drive to build a multi-million-dollar poultry industry that is expected to boost rural incomes and nutrition, in line with Vision 2030. The Government wants to make Zimbabwe one of the biggest exporters of eggs,...

Research Update Nov. 15, 2021 Image credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health. Used under the terms of CC BY-NC 2.0. Researchers have identified a new bodily defense mechanism deployed in the fight against urinary tract infections (UTIs). UTIs are very common in adults as well as in about 8 percent of children, most frequently girls. The leading cause of UTIs is exposure to uropathogenic E. coli bacteria, also referred to as UPEC. While antibiotics resolve many infections, recurrence is common, and antibiotic resistance is rising; a better understanding of the natural course of UTIs could help lead to new treatments. In addition to flushing bacteria and infected bladder cells out of the urinary tract through urination, the body employs innate defenses, such as production of antimicrobial molecules, to stymie UTIs. In a new study, scientists examined one such molecule, the protein ribonuclease 7, t...

Has the over-use of antibiotics created a deadly risk to newborns? Kamala Thiagarajan investigates the hidden health crisis devastating families around the world – and the solutions that could stop it. When Mukta's baby boy was born in December 2021 in Dhaka, Bangladesh, it quickly became clear to doctors that he needed emergency care. The 32-year-old mother, who prefers to go by her first name, and her husband had struggled to conceive for 11 years before she finally became pregnant following infertility treatment. Due to complications during the pregnancy, her baby was delivered prematurely by emergency caesarian at 32 weeks. Her son weighed just 1.4kg (3lbs) and was put on ventilator support. He was also injected with antibiotics to prevent bacterial infections that affect the bloodstream – a life-threatening condition known as neonatal sepsis. While her son appeared to do well at first, things took a turn for the worse when he was 11 days old. He was lethargic, and the oxyg...