ORF Virus Treatment

No human genome has ever been read in its entirety before. This year, scientists expect to pass that milestone for the first time. Before the end of 2023, you should be able to read something remarkable. It will be the story of a single individual, who they are and where they come from – and it will offer hints about what their future holds. It probably won't be the most entertaining read on first glance, and it will be very, very long. But it will be a seminal moment – the publication online of the entire genome of a human being, end to end with no gaps. At this point you may feel that you have heard this before. Surely the human genome was published decades ago? Isn't that all done? It was, in fact, never finished. The first draft of the human genome was released in 2001, before a consortium of international scientists of the Human Genome Project announced that they had "completed" the job with a finished sequence in 2003. Assembled from chunks of vario...

February 07, 2023 2 min read Source/Disclosures Disclosures: Press reports receiving grant funding from AHRQ, American Lung Association and NIH; receiving consultant fees from Humana and Vizient; and participating on NIH R34, a data safety monitoring board. Please see the study for all other authors' relevant financial disclosures. Buhr reports receiving support from the COPD Foundation, NIH, Novartis and Sunovion; grants from NIH/NCATS and NIH/NHLBI; consultant fees from the American College of Physicians/DynaMed and 2ndMD; and payments from Theravance Biopharma/Viatris. Krishnan reports receiving support from the COPD Foundation and NHLBI; receiving grants from American Lung Association, Patient Centered ...

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Research Highlights: Black women of childbearing age were more than twice as likely to have uncontrolled blood pressure than white women of similar age, putting them at an increased risk of pregnancy-related complications. This disparity in high blood pressure persisted after adjusting for social determinants of health, health factors and modifiable health behaviors. Food insecurity — lack of access to adequate healthy food — one of the social factors that may affect high blood pressure risk, was higher among Hispanic and Black women compared with white women.  The research is featured in a special Go Red for Women issue of the Journal of the American Heart Association focused on research in women. Embargoed until 4 a.m. CT/5 a.m. ET, Monday, Feb. 27, 2023 DALLAS, February 27, 2023 — Black women of childbearing age were twice as likely to have uncontrolled high blood pressure when compared with their white peers, increasing their risk of ...

John McMurray, MD, PhD Courtesy: University of Glasgow A patient-level pooled meta-analysis of the DAPA-HF and DELIVER trials suggests gout was present in 10% of patients and associated with worse outcomes, but also indicate benefits of dapagliflozin were consistent in patients with heart failure regardless of whether or not they had a diagnosis of gout. Results of the study, which included data from more than 11,000 patients with gout history available, demonstrated use of dapagliflozin was not only associated with significant reductions in the trials' primary outcomes for patients with gout, but also associated with a reduction in the need to initiate uric acid–lowering therapy and treatment with colchicine. "In this posthoc analysis of 2 phase 3 clinical trials, the beneficial effect of dapagliflozin use with clinical outcomes was consistent among patients with heart failure irrespective of gout status. Dapagliflozin reduced the initiation of medications used to reduce urat...

Krystina Pacheco, 29, of Pleasanton, Texas, gave birth to her daughter Amelia on Oct. 24, 2022, in what she described as an uneventful C-section delivery. Two days later, on the day she was discharged from the hospital, Pacheco said she started feeling feverish but assumed it was just part of her recovery post-C-section and was given ibuprofen by a nurse. Southern Kindred Studios Jacob and Krystina Pacheco pose with their toddler son during Krystina's pregnancy with their second child. When she continued to feel unwell at home, Pacheco said she went to see a doctor, who sent her to a local emergency room. From there, Pacheco was airlifted to a hospital in San Antonio, where doctors discovered her body was in septic shock. "I just remember I couldn't breathe anymore and I couldn't see anymore and I just started slowly fading out," Pacheco told ABC News. "My husband, I could just hear him saying, 'Please come back to us, please, your babies need you. I need...

There's an old saying in the field of technology: "Nobody ever got fired for buying IBM" — a reference to the company's once-ubiquitous computers. Replace IBM with Illumina, a biotechnology company in San Diego, California, and the same could be said of DNA sequencing today. Keith Robison, a computational biologist at Ginkgo Bioworks in Boston, Massachusetts, who writes about sequencing technologies on a blog called Omics! Omics!, says that for most laboratories, Illumina "is the really safe bet out there". However, IBM's days of computer market dominance are well in the past, and Illumina now faces multiple competitors who are looking to challenge — and perhaps unseat — the current giant of the sequencing marketplace. Researchers, naturally, are paying attention. Pedro Oliveira heads the DNA-sequencing lab at the French National Sequencing Center, also known as Genoscope, in Évry. The lab recently partnered with several big European research projects, i...

Dr. Edward Nardell has dedicated close to a half century of his life to the study and examination of airborne infections such as tuberculosis and the use of ultraviolet irradiation for disinfecting indoor air. After completing his pulmonary medical training at Massachusetts General Hospital in 1977, he began working for the Boston Department of Public Health.  Two events in the mid-80s, an outbreak of TB among Haitian immigrants in Cambridge and then the resurgence of TB reinfections at the Pine Street Inn homeless shelter in Boston, shaped Nardell's life-focus in its current direction. In considering how he could stop TB, he recalled a lecture by famed pulmonologist and TB expert Dr. Richard Riley, who had recently retired. Riley had explained that ultraviolet (UV) germicidal irradiation was very efficient at killing airborne bacteria and viruses.  Nardell contacted Riley, who guided him on the installation of upper room UV fixtures (near or at ceiling level). Th...