ORF Virus Treatment

BioNTech SE First-in-human study aims to evaluate the safety and immunogenicity of prophylactic herpes virus vaccine candidate BNT163 BNT163 is the first candidate from BioNTech's infectious disease mRNA vaccine collaboration with the University of Pennsylvania to enter the clinic The program is part of BioNTech's strategy to address diseases with high unmet medical need, as no vaccine has been approved for prevention of genital lesions caused by HSV MAINZ, Germany, December 21, 2022 – BioNTech SE (Nasdaq: BNTX, "BioNTech" or the "Company") today announced that the first subject was dosed in a first-in-human Phase 1 clinical research study with BNT163, a herpes simplex virus (HSV) vaccine candidate for the prevention of genital lesions caused by HSV-2 and potentially HSV-1. The trial ( NCT05432583 ) will evaluate the safety, tolerability, and immunogenicity of BNT163. The mRNA vaccine encodes three HSV-2 glycoproteins with the aim of helping to prevent HSV...

Aspergillus is a ubiquitous fungus that can lead to a spectrum of clinical syndromes. The degree of immunosuppression of the host determines the clinical manifestations, course, and prognosis of the disease, even though there is an increasing concern about genetics as a predisponent factor. Most people who have contact with this microorganism do not develop lung disease. Invasive pulmonary aspergillosis (IPA) is at one end of the spectrum, affecting patients with severe defects in immune function, such as neutropenia, hematopoietic stem cell transplant (HSCT), or solid organ transplant recipients, advanced Acquired Immunodeficiency Syndrome (AIDS), chronic granulomatous disease and patients undergoing chemotherapy or on long-term therapy with high-dose corticosteroids [1]. Sometimes, pulmonary aspergillosis can have an indolent course, affecting patients with mild or no immunocompromise but with underlying lung disease [1]. Symptoms are nonspecific and ...

Antibiotic resistance, when infection-causing bacteria evolve so they are no longer affected by typical antibiotics, is a global concern. New research at the University of Tokyo has mapped the evolution and process of natural selection of Escherichia coli ( E. coli ) bacteria in the lab. These maps, called fitness landscapes, help us better understand the step-by-step development and characteristics of E. coli resistance to eight different drugs, including antibiotics. Researchers hope their results and methods will be useful for predicting and controlling E. coli and other bacteria in the future. Have you ever felt queasy after eating an undercooked burger? Or when leftovers from yesterday's dinner were left out of the fridge a bit too long? There are many different kinds of food poisoning, but one common cause is the growth of bacteria such as E. coli . Most cases of E. coli , though unpleasant, can be managed at home with rest and rehydration. However, in some instances, i...

A team of researchers from the University of Copenhagen has looked to the microbiome to understand what role gut bacteria may play in weight gain. The findings suggest certain populations of bacteria are more efficient at extracting energy from food, and this could be why some people easily pile on the pounds from relatively healthy diets. Over the last couple of decades, a handful of studies found fascinating links between obesity and the gut microbiome. For example, fecal transplant studies saw thin mice gain substantial weight when colonized with gut bacteria from obese mice. And one hypothesis suggested the key factor differentiating obese and lean animals was their microbiome's capacity for harvesting energy from food. We know the bacteria in out gut plays an important role in digestion. Metabolites from different bacteria can help degrade food into carbohydrates and lipids, so when we eat we are also treating the microbes in our gut to a feast. And those microbes do influence...

Julie Schellack credits free financial counseling with putting her in a position to buy her first home last year. She heard about the counseling from Lutheran Social Service of Minnesota through an email from her employer, Hennepin County, and thought it could help her. Even after just one meeting in 2019, financial counseling supervisor Dan Park helped her turn her finances around. "He gave me the tools and knowledge I needed to p...

Chlamydia is the most common STI caused by bacteria, but because it's typically asymptomatic, many people can have it and not know it. (Photo: Getty Images) There are more than 20 types of sexually transmitted infections (STIs), but some are more prevalent than others — namely, chlamydia, which is the most common STI caused by bacteria. (HPV, also known as human papillomavirus, is the most common STI caused by a virus.) In fact, chlamydia trachomatis — the bacteria behind chlamydia infections — is "responsible for the greatest number of sexually transmitted infections" worldwide. In 2020, nearly 1.6 million cases of chlamydia were reported in the U.S, according to the Centers for Disease Control and Prevention (CDC), "making it the most common notifiable sexually transmitted infection in the United States for that year." As Dr. Saahir Khan, infectious disease expert with Keck Medicine of USC, tells Yahoo Life: "Chlamydia has been infecting humans for mille...

[unable to retrieve full-text content] Board of Health recommends Gary Dale, M.D. | News ...    Choteau Acantha

Want to learn how you can empower yourself as a patient? This workshop will teach you how to find trusted health information on the internet, whether it's for researching symptoms, injuries, diseases, or finding treatments and care near you. This is a demonstrative and interactive workshop; bring your own e-device (smartphone/tablet/laptop), or use one of the library's. Open to anyone who is interested! This workshop takes place in-person at Sequoya Library on Saturday, January 7 from 2-3PM. No registration required.  About the presenter:   Olivia Zhu is passionate about technology and healthcare! The president of the MEDLIFE (Medicine, Education, and Development for Low-Income Families Everywhere) chapter at Vel Phillips Memorial High School, where she is currently a senior, and the founder of DCYTHE (Dane County Youth for Technology, Health and Education), Olivia has partnered with Wisconsin Health Literacy to offer this free and intera...

Becky By Emma Hallett BBC News Just over a year ago Toby was a seven-year-old boy, running around and playing with his friends, but after suddenly contracting bacterial meningitis, he became paralysed, was unable to eat and lost the power of speech. Following a year of intensive physiotherapy at Bristol children's hospital he is walking again and has been able to go to a new school in Swindon where he receives one-to-one support. His mother, Becky, wanted to tell his story to raise awareness about the disease. "To hear him call me Mum again, and see him respond well [to treatment] has turned a horrible year into the best dream ever," Becky said. On 11 November 2021, Toby was admitted to the Paediatric Intensive Care Unit (PICU) at Bristol Royal Hospital for Children. He had been suffering with a high temperature for a couple of days, had complained of neck ache and was not eating. Mother-of-five, Becky, from Pinehurst in Swindon, said she thought he had a stomach bug, but...

[unable to retrieve full-text content] Autoimmune meningoencephalitis associated with anti‐glutamic ...    Wiley

Morgan felt slightly better on Wednesday and didn't want to miss another day of university so she went back. On Thursday morning, she couldn't stop shaking and felt like she was about to pass out. She ended up in the A&E that day but further tests revealed nothing. Unfortunately, her symptoms kept getting worse, with extreme rigor and pain in her chest, back, and shoulders taking over her body. It wasn't until a second trip to the emergency department that she finally got some answers. The 19-year-old was hit by Lemierre's syndrome, a rare illness that occurs when bacteria from a throat infection crosses into the jugular veins. READ MORE:  Thousands of triple vaccinated Britons reporting same Covid symptom - 54% of all cases 

Share on Pinterest Researchers recently developed an effective vaccine tablet for urinary tract infections that dissolves under the tongue. Caroline Purser/Getty Images Researchers recently developed a sublingual vaccine tablet for urinary tract infections that dissolves under the tongue. In animal models, the vaccine was as effective as high dose antibiotics in treating UTIs without negative side effects on the gut microbiome. Further studies are needed to determine how these findings may translate to humans. About half of all women experience a urinary tract infection (UTI) in their lifetime. Of these women, 27% have a confirmed recurrence within the next 6 months. People with recurrent UTIs experience more than three infections each year. Recurrent UTIs are often managed using long-term antibiotics, which can alter the gut microbiota and cause adverse side effects. Uropathogenic Escherichia coli (UPEC), which causes around 80% of uncomplicated UTIs, is becoming increasingly resi...