ORF Virus Treatment

1 INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China, in December 2019. Since then, the virus has rapidly spread across the world due to its high transmissibility and the World Health Organization (WHO) declared COVID-19 as a pandemic on March 11, 2020. Clinical manifestations among pediatric patients are generally less severe than those seen in adults, but the proportion of severe and critical cases reported in children inversely correlates with their age at presentation, with more severe cases reported in infants less than one year of age. 1, 2 Nonetheless, early reports on neonatal SARS-CoV-2 infections were reassuring, with most cases showing an asymptomatic course or rarely symptomatic uncomplicated diseases. 3, 4 As the pandemic evolved, however, reports of neonatal acute respiratory distress syndrome have been increasingly ...

Abstract SARS-CoV-2 (CoV) is the etiological agent of the COVID-19 pandemic and evolves to evade both host immune systems and intervention strategies. We divided the CoV genome into 29 constituent regions and applied novel analytical approaches to identify associations between CoV genomic features and epidemiological metadata. Our results show that nonstructural protein 3 (nsp3) and Spike protein (S) have the highest variation and greatest correlation with the viral whole-genome variation. S protein variation is correlated with nsp3, nsp6, and 3′-to-5′ exonuclease variation. Country of origin and time since the start of the pandemic were the most influential metadata associated with genomic variation, while host sex and age were the least influential. We define a novel statistic—coherence—and show its utility in identifying geographic regions (populations) with unusually high (many new variants) or low (isolated) viral phylogenetic diversity. Interestingly, at both global and regional ...

The retina is the innermost layer of the eye, and it features many light-sensitive photoreceptor cells. These cells detect light and convert it into electrical signals, which travel through the optic nerve to the brain, resulting in sight. Retinal disorders affect the retina and typically result in visual problems. The human eye is a specialized organ that reacts to light and allows people to see. The eye has many structures that enable vision, including the retina. Retinal disorders are conditions that affect any part of the retina. Some can mildly affect a person's vision, while others may lead to blindness. However, it may be possible to prevent most retinal disorders if an eye doctor identifies the condition early and provides appropriate treatment. If a person is experiencing problems with their retina, they may need to see an ophthalmologist. This is a medical professional who specializes in ophthalmology, or eye care. In particular, a person may need to visit an eye doctor w...

Just days after being discovered in South Africa, the new possibly more infectious omicron strain of the coronavirus has appeared in additional European nations, sending governments around the world rushing to stem the spread. Following the discovery of two instances, the UK strengthened its requirements on wearing masks and testing overseas visitors on Saturday. Also read | Israel becomes the first country to shut all borders over fear of new variant New instances were reported on Saturday in Germany and Italy, with the variation also being detected in travellers in Belgium, Israel, and Hong Kong. In the United States, Dr Anthony Fauci, the government's top infectious disease specialist, said he wouldn't be shocked if the omicron version was also present.  Watch: EU, US restrict travel from South Africa to contain new coronavirus variant "We have not detected it yet, but when you have a virus that is showing this degree of transmissib...

[unable to retrieve full-text content] Optimised versus standard dosing of vancomycin in infants with Gram-positive sepsis (NeoVanc): a multicentre, randomised, open-label, phase 2b, non-inferiority trial    The Lancet